By UC Davis News and Media Relations
Young women today may face increased health risks linked to breast cancer due to effects from a banned toxic pesticide lasting over three generations, according to a new study from the Public Health Institute’s Child Health and Development Studies, or CHDS, and the University of California, Davis.
In the first study to report on the health effects of exposure to a toxic environmental chemical over three human generations, the new study found that granddaughters whose grandmothers were exposed to the pesticide DDT have higher rates of obesity and earlier first menstrual periods. This may increase the granddaughters’ risk for breast cancer as well as high blood pressure, diabetes and other cardiometabolic diseases.
The research was published today in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. DDT was banned in the U.S. nearly 50 years ago. Yet the study suggests that effects from DDT may contribute to the falling age of first periods and increases in obesity rates among young women today.
The study found that the risk of obesity in young adult granddaughters was two to three times greater when their (not overweight) grandmothers had higher levels of o,p’-DDT — a contaminant of commercial DDT — in their blood during or just after pregnancy. Granddaughters were twice as likely to have earlier first menstrual periods when their grandmothers had higher o,p’-DDT blood levels. DDT and its related chemicals are known to be endocrine-disrupting chemicals, which are compounds that can alter and interfere with natural hormones essential for development.
“We already know that it’s nearly impossible to avoid exposures to many common environmental chemicals that are endocrine disrupters,” said Barbara Cohn, director of CHDS and senior author of the study. “Now our study shows for the first time in people that environmental chemicals like DDT may also pose health threats to our grandchildren. In combination with our ongoing studies of DDT effects in the grandmother’s and mother’s generations, our work suggests we should take precautionary action on the use of other endocrine disrupting chemicals, given their potential to affect generations to come in ways we cannot anticipate today.”
Generations of risk
The Child Health and Development Studies has followed 20,000 pregnant women and their families for more than 60 years. CHDS enrolled and began following pregnant women in the Bay Area between 1959 and 1967, a time of high pesticide use before DDT was banned in 1972. These “founding grandmothers” in the study gave blood samples at each trimester during pregnancy and one sample shortly after birth. The blood samples were tested for levels of DDT and its related chemicals, including active ingredients, contaminants and their metabolites.
The study today focuses on o,p’-DDT as it has previously been linked to breast cancer, obesity and other harmful health effects in daughters, and is believed to be the most sensitive biomarker for exposures before and immediately after birth. Since granddaughters’ exposure would occur via their mothers’ in utero egg cell development, o,p’-DDT levels are a potential predictor of granddaughters’ exposure outcomes.
“These data suggest that the disruption of endocrine systems by DDT initiates in immature human eggs, decades before the eggs are fertilized,” said co-leading author Michele A. La Merrill, an associate professor of environmental toxicology at UC Davis.
The CHDS study included interviews, home visits and questionnaires from the daughters and granddaughters of the original enrollees. During home visits, blood pressure and height and weight measurements were taken. The study today is based on 365 adult granddaughters who completed questionnaires, participated in a home visit, had available DDT measures from grandmothers’ serum, and (for 285 of them) had available information on body mass index in all three generations. Information on the age of first period for all three generations was available from 235 granddaughters.
Previous CHDS studies have shown that mothers’ DDT exposure during pregnancy or immediately after birth correlates with increased daughters’ risk of breast cancer and the prevalence of breast cancer risk factors, including obesity, among adult daughters. Other prior studies have linked DDT exposure to birth defects, reduced fertility and an increased risk of diabetes.
The research published today was supported by the California Breast Cancer Research Grants Program, the Breast Cancer Environment Research Program of the National Institute of Environmental Health Sciences (NIEHS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the USDA National Institute of Food and Agriculture.